Most dogs with Cushing’s are treated with a daily oral medication that suppresses the overproduction of cortisol. The most commonly prescribed medication is Trilostane (brand name: Vetoryl®). It works by inhibiting the enzymes that produce cortisol in the adrenal glands.

It’s important to note that no single test is perfect. Your veterinarian may recommend multiple tests or repeated monitoring, especially if your dog has other medical conditions that could affect the results.

One of the first—and most telling—symptoms pet owners often notice is increased thirst and urination. A dog with Cushing’s may begin emptying the water bowl faster than usual and needing to go outside much more frequently, even having accidents in the house. This change is often what prompts owners to schedule a veterinary exam.